Key Terms :
Human intestinal absorption: Human Intestinal Absorption (HIA) after oral administration.
Aqueous solubility: The solubility of each compound in water at 25°C.
Plasma protein binding: Compound is likely to be highly bound to carrier proteins in the blood.
Blood brain barrier penetration: The blood brain barrier penetration of a molecule, defined as the ratio of the concentrations of solute (compound) on the both sides of the membrane after oral administration, and reports the predicted penetration as well as a classification of penetration level.
CYP2D6 binding: Cytochrome P450 2D6 enzyme inhibition and reports whether or not a compound is likely to be an inhibitor.
Hepatotoxicity: Occurrence of dose-dependent human hepatoxicity.
Ames mutagenicity : Ames test is a widely employed method that uses bacteria to test whether a given chemical can cause mutations in the DNA of the test organism. Mutagenicity refers to the induction of permanent transmissible changes in the amount or structure of the genetic material of cells or organisms.
Developmental toxicity : Developmental toxicity is any structural or functional alteration, reversible or irreversible, which interferes with homeostasis, normal growth, differentiation, development or behavior.
Skin irritancy and sensitization : The state of feeling annoyed, impatient, or slightly angry. Skin sensitization is an immunological response to previous exposure to a substance which results in an inflammatory skin reaction. Previous exposure to a specific substance is necessary for skin sensitization.